Intraventricular insulin reduces food intake and body weight of marmots during the summer feeding period

Intraventricular GLP-1 reduces short- but not long-term food intake or body weight in lean and obese rats.

Glucagon-like-peptide-1 (7-36) amide (GLP-1), when infused into the third ventricle (I.V.T.), reduces short-term food intake. In the present experiments, we assessed whether I.V.T. administration of GLP-1 could influence long-term food intake and body weight of lean Long Evans rats and of fatty Zucker (fa/fa) rats. In Experiment 1, we replicated the observation that 10 microg GLP-1, given I.V.T...

PYY(3-36) reduces food intake and body weight and improves insulin sensitivity in rodent models of diet-induced obesity.

The gut hormone peptide YY (PYY) was recently proposed to comprise an endogenous satiety factor. We have studied acute anorectic functions of PYY(3-36) in mice and rats, as well as metabolic effects of chronic PYY(3-36) administration to diet-induced obese (DIO) mice and rats. A single intraperitoneal injection of PYY(3-36) inhibited food intake in mice, but not in rats. We next investigated th...

Leptin and the Regulation of Food Intake and Body Weight.

The effects of morphine and nicotine co-administration on body weight, food intake and appetite-regulating peptides in rats

Previous studies in humans and animals have reported that nicotine administration decreases body weightand caloric intake. Opiate and cigarette have been used concomitantly as drug abuse. The aim of the present study was, therefore, to analyze the effect of chronic co-administration of nicotine and morphine on food intake, body weight and on some feeding-associated peptides. All experiments wer...

Activation of murine pre-proglucagon-producing neurons reduces food intake and body weight.

Peptides derived from pre-proglucagon (GCG peptides) act in both the periphery and the CNS to change food intake, glucose homeostasis, and metabolic rate while playing a role in anxiety behaviors and physiological responses to stress. Although the actions of GCG peptides produced in the gut and pancreas are well described, the role of glutamatergic GGC peptide-secreting hindbrain neurons in reg...